Ultimate-E contains all of the natural isomers of vitamin E. Tocopherols provide protection from free radicals and products of oxygenation, including lipid peroxides and singlet oxygen radicals. Gamma-tocopherol inhibits the enzyme cyclooxygenase, whereas alpha-tocopherol does not appear to have a significant effect on this enzyme. Human studies comparing diets supplemented with both gamma- and alpha-tocopherols (more gamma than alpha) to diets supplemented primarily with alpha-tocopherol found more DNA protection in the mixed-tocopherol group than in the alpha-tocopherol-only group.

Antioxidants such as vitamin E are vital to the overall antioxidant capacity in the blood and tissues. Numerous clinical studies have shown vitamin E is beneficial to the cardiovascular system, and recent studies looking at mixed tocopherols have indicated they have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone, indicating a more potent antioxidant effect of mixed tocopherols. Supplementing with Ultimate-E, with its naturally occurring ratio of tocopherols, is an efficient way to supplement the vitamin E molecules – without the addition of soy oil as a filler.

Thorne's Ultimate-E contains pure, undiluted vitamin E. The vitamin E is extracted from a mixture of vegetable oils, including soy oil. However, any potentially allergenic soy residues are removed during the distillation process and, unlike most vitamin E products on the market, Ultimate-E is not diluted with soy oil. Because the tocopherols come from a natural source, the exact tocopherol profile can vary slightly from batch to batch, although extra alpha-tocopherol is added to each batch to standardize the amount of this important tocopherol to 500 IU per capsule.